Calcifying nanoparticles induce apoptosis and calcification in bone marrow mesenchymal stem cells <i>via</i> the transforming growth factor-β/Smad pathway
CNPs and nHAPs induced apoptosis and calcification in BMSCs, with CNPs being the most potent. Additionally, the TGF-β inhibitor SB431542 significantly reduced the occurrence of apoptosis and calcification. A correlation was found between apoptosis and calcification, which is likely mediated through the TGF-β/Smad signaling pathway.
Authors
- Xiangwei Wu (ORCID: https://orcid.org/0000-0002-3897-6629)
- Sanqiang Niu
- Hongwei Zhang (ORCID: https://orcid.org/0000-0002-6294-1143)
- F. Xu (ORCID: https://orcid.org/0000-0002-8166-0275)
- Hao-Jie Shi
- Mei-Yan Wang
- Xin-Yu Peng
- Zhen-Hao Li
- Xuan-Li Su
- Pankaj Bagari
- Yu-Fan He
- Jian Yang
Institutions
- Shihezi University (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-12-25
- DOI
- https://doi.org/10.4252/wjsc.v17.i12.106128
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00