Leveraging Digital Speech Features for Early Identification of Alzheimer's Disease: Associations with structural and functional brain changes over time
Phone-based cognitive assessments hold promise as a remote and scalable tool for identifying AD-related structural and functional brain changes. They offer predictive value for cognitive trajectories in pre-dementia populations. This approach could aid in identifying individuals at risk while guiding further evaluation, broadening their utility beyond cognitive screening.
Authors
- Anja Schneider (ORCID: https://orcid.org/0000-0002-3377-5828)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Gabor C. Petzold (ORCID: https://orcid.org/0000-0002-0145-8641)
- Qingyue Li
- Christoph Laske (ORCID: https://orcid.org/0009-0009-3434-936X)
- Luca Kleineidam (ORCID: https://orcid.org/0009-0006-3309-6856)
- Elisa Mallick
- Björn Falkenburger (ORCID: https://orcid.org/0000-0002-2387-526X)
- Zoi Alexopoulou (ORCID: https://orcid.org/0000-0002-1785-1800)
- Fedor Levin (ORCID: https://orcid.org/0000-0002-0518-1715)
- Melina Stark (ORCID: https://orcid.org/0009-0005-3812-023X)
- Josef Priller
- Inga Zerr
- Jens Wiltfang
- Nicklas Linz
- Frank Jessen
- Martin Dyrba
- Emrah Düzel
- Stefan J. Teipel
- Stefanie Köhler
- Michael Wagner
- Alexandra König
Institutions
- University of Bonn (DE)
- University of Cologne (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- UK Dementia Research Institute (GB)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Cognition Behaviour Technology (FR)
- University Hospital Cologne (DE)
- University Hospital Carl Gustav Carus (DE)
- University of Rostock (DE)
- University of Aveiro (PT)
- Technical University of Munich (DE)
- University of Göttingen (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_098534
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00