Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease
In this real-world dataset, we identified effects of multimorbidities on plasma biomarkers, especially kidney function. The p-tau<sub>217</sub>/Aβ<sub>42</sub> ratio had low rates of Intermediate classification and may help to account for multimorbidity effects on plasma levels. ANN NEUROL 2026;99:1030-1045.
Authors
- Colleen Morse
- L. Shaw
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Rory Boyle (ORCID: https://orcid.org/0000-0003-0787-6892)
- Nadia Dehghani (ORCID: https://orcid.org/0000-0002-0385-7267)
- P. PennMedicine Biobank
- K. O'Flynn O'Brien
- Katheryn AQ Cousins
- Edward B. Lee
- Marina Serper
- Anurag Verma
- Christopher A. Brown
- Corey T. McMillan
Institutions
- Hospital of the University of Pennsylvania (US)
- Penn Center for AIDS Research (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1002/ana.78114
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- University of Pennsylvania
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- Perelman School of Medicine, University of Pennsylvania
- National Center for Advancing Translational Sciences