Harnessing CRISPR–Cas9 and CRISPRi systems to reverse antibiotic resistance in a clinical multidrug-resistant <i>Escherichia coli</i> isolate
In this study, CRISPR-based systems effectively reversed multidrug resistance in a clinical E. coli isolate, advancing the applications of CRISPR systems in controlling bacterial multidrug resistance.
Authors
- Honghao Huang (ORCID: https://orcid.org/0000-0002-3487-1790)
- Qi Li (ORCID: https://orcid.org/0000-0001-8227-7035)
- Zhenling Zeng
- Wenguang Xiong
- Ruonan Zhao
- Peng Wan
Institutions
- South China Agricultural University (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1093/jac/dkaf442
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00