Inflammation‐Linked Microbiome Alterations Associated with Cognitive Impairment in Older Adults: Insights from the MiaGB Consortium
These findings reveal that butyrate-producing genera such as Lachnospira, Akkermansia, and Subdoligranulum are significantly reduced, while potentially pathogenic Fusicatenibacter and commensal Prevotella are elevated in individuals with MCI and high IL-6 levels. These distinct microbial profiles may serve as biomarkers for the early detection of cognitive decline in older adults, highlighting potential targets for therapeutic strategies to preserve brain health during aging.
Authors
- Jeff Hoover
- Adam G. Golden (ORCID: https://orcid.org/0009-0005-6885-6686)
- Rohit Shukla (ORCID: https://orcid.org/0000-0001-8279-5377)
- Peter Holland (ORCID: https://orcid.org/0000-0001-7256-2545)
- Sidharth P. Mishra (ORCID: https://orcid.org/0000-0001-7586-846X)
- Vivek Kumar (ORCID: https://orcid.org/0000-0003-4737-3288)
- Shalini Jain (ORCID: https://orcid.org/0000-0001-5200-5928)
- Lauren Buddendorff
- Cynthia White Williams
- Hariom Yadav
- Dhananjay Yadav
- Corrie Labyak
- Michal M Masternak
- Marc Agronin
Institutions
- University of Central Florida (US)
- University of South Florida (US)
- Academy of Nutrition and Dietetics (US)
- Florida Atlantic University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104153
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00