Restoring Cell–Cell Junctions in <i>DSPP</i> ‐Deficient Odontoblasts Through Nanofibrous Topography and Wnt5a‐Cdc42 Activation: A Laboratory Investigation
The results provide evidence that Dspp contributes to the structural integrity of dentine by modulating ZO-1 and Cx43 expression and suggest that biomaterial and molecular interventions may offer supportive strategies to restore dentine structure and function in DGI-affected teeth, though they do not address the underlying genetic defect.
Authors
- Jung‐Wook Kim
- Jieun Bae (ORCID: https://orcid.org/0000-0001-7240-2592)
- Kyung Mi Woo
Institutions
- Seoul National University (KR)
- Seoul National University Dental Hospital (KR)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1111/iej.70086
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea