Essential Role of α5‐GABAA Positive Allosteric Modulation in Cognitive Functions in a Mouse Model of Amyloid Deposition
Our findings demonstrated that the effects of GL-II-73 are mediated by allosteric modulation of the benzodiazepine-binding site of α5-GABAARs, as expected, specifically at improving working memory and spatial cognition.
Authors
- James M. Cook (ORCID: https://orcid.org/0000-0001-5512-3022)
- Prithu Mondal
- Michael Marcotte (ORCID: https://orcid.org/0009-0008-5291-8776)
- Carla Elena Mezo‐González (ORCID: https://orcid.org/0000-0002-2389-1796)
- Dishary Sharmin (ORCID: https://orcid.org/0000-0003-0417-4262)
- Etienne M. Sibille
- Jingxin Chen
- Thomas D Prevot
Institutions
- Centre for Addiction and Mental Health (CA)
- University of Wisconsin–Milwaukee (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_101133
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00