Neuropsychiatric Phenotypes in Cognitively Unimpaired Older Adults: Associations with Clinical Progression and Domain‐Specific Cognitive Trajectories
Distinct NPS phenotypes were observed among CU older adults and were associated with differing risks of MCI/dementia progression and cognitive trajectories. Phenotypes with high NPS, particularly agitation, anxiety, and irritability, showed higher odds of progression than depressive symptoms alone. These findings underscore the value and potential utility of early NPS patterns for predicting cognitive decline and early risk detection.
Authors
- Emily C. Edmonds (ORCID: https://orcid.org/0000-0002-5130-0500)
- Alexandra J. Weigand (ORCID: https://orcid.org/0000-0002-7931-1383)
- Caitlin M. Terao (ORCID: https://orcid.org/0000-0002-5506-9625)
- Shanna Cooper (ORCID: https://orcid.org/0000-0003-0498-7044)
- Fareshte R. Erani (ORCID: https://orcid.org/0000-0001-6517-7980)
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
- Katherine J. Bangen
Institutions
- Alzheimer's Association (US)
- University of Arizona (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- San Diego State University (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- Banner Alzheimer’s Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_097877
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00