Traumatic Brain Injury‐associated gene network‐based prediction and population‐based validation identifies doxycycline as a repurposable medicine for Alzheimer’s Disease
We demonstrated that combining network-based predictions and large real-world patient data observations can be used to identify potential repurposable drugs for AD based on combined AD-TBI associated genes within the human protein interactome. This has led to identifying doxycycline as a candidate treatment for preventing AD.
Authors
- Ehud Karavani (ORCID: https://orcid.org/0000-0002-0187-5437)
- Michael M. Danziger (ORCID: https://orcid.org/0000-0002-2674-0109)
- Andrew A. Pieper
- Reina Tonegawa Kuji
- Marina Bykova
- Feixiong Cheng
- Michal Rosen‐Zvi
Institutions
- Cleveland State University (US)
- Cleveland Clinic (US)
- University Hospitals of Cleveland (US)
- Cleveland Clinic Lerner College of Medicine (US)
- University Hospitals Cleveland Medical Center (US)
- Louis Stokes Cleveland VA Medical Center (US)
- IBM Research - Haifa (IL)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_103656
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00