Active Seizures are Associated with Worse Instrumental Activities of Daily Living in Individuals with Normal Cognition and Dementia

Active seizures are associated with worse IADL performance regardless of cognitive status. Active seizures are also associated with a significantly faster rate of decline in IADLs in cognitively normal individuals. These findings suggest the need to assess IADLs in routine clinical care in older PWS to identify those needing assistance and for aggressive seizure management to preserve independence in at-risk populations.