A Rapid Method Based on Colloidal Selenium Nanoparticle to Detect NT-proBNP Antigen in Serum for Monitoring Acute Heart Failure
The developed single-step immunochromatographic method utilizing PEG20000 and SDS-modified colloidal selenium demonstrates meaningful potential for the rapid and reliable detection of NT-proBNP in serum samples from clinical patients. The colloidal selenium immunochromatographic technique developed in this study was assessed from the aspect of material synthesis, and the conditions for the application of this test paper were screened to verify the high specificity of the test paper, which met the criteria of the Chinese Heart Failure Diagnosis and Treatment Guidelines 2024 for acute heart failure.
Authors
- Tao Chen (ORCID: https://orcid.org/0000-0002-5489-6450)
- Jun Shao (ORCID: https://orcid.org/0000-0001-8529-4682)
- Chengbin Tang
- Hongguang Xiang
- Ye Shen (ORCID: https://orcid.org/0000-0003-4157-5604)
- Jigao Zhu
- Ling Gu
- Ye Zhu
Institutions
- China Pharmaceutical University (CN)
- Xuzhou Medical College (CN)
- Taixing People's Hospital (CN)
- Northern Jiangsu People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/ijn.s547434
- Primary Topic
- Biosensors and Analytical Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province