Quantification of 18F Flutemetamol PET SUVr to Centiloid scale: a local clinical application

In the first and second part, correlation analysis obtained a slope of 1.0147 and 1.3029 with R2 of 0.9816 and 1 respectively, which met the expectation of calibration. For the local application, a linear correlation is obtained for SUVr obtained in image retrieved vs SUVr in cortex ID, with SUVr(cortexID)=SUVr(image)*0.9746, with R2 of 0.9968. The final CL can be calculated directly with the formula CL=124.58* SUVr(cortexID)-121.16 CONCLUSION: This study achieved the aim to obtained a direct conversion formula for SUVr (Cortex ID) to CL. This would help clinicians for image reporting, compare the Aβ PET results across sites and studies, and facilitate Aβ treatment prescription.