Leveraging Enhanced Hi‐C Capture Analysis (eHiCA) to identify susceptibility genes in ambiguous GWAS loci for Alzheimer's disease: evidence for known and unusual suspects
This initial application of eHiCA on ambiguous AD GWAS loci demonstrates the utility of chromatin regulatory maps in nominating candidate genes of GWAS hits in non-coding loci which lack clear candidates. This extended application of eHiCA will broaden our understanding of AD genomics overall.
Authors
- Juan I. Young
- Theresa Schuck
- Leina Lu (ORCID: https://orcid.org/0000-0001-9878-1068)
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Wanying Xu (ORCID: https://orcid.org/0009-0000-3262-2013)
- Katrina Celis
- Karen Nuytemans (ORCID: https://orcid.org/0000-0003-2670-4914)
- Jeffery M. M Vance
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- Sandra Weintraub
- Luciana Bertholim Nasciben
- Margaret Pericak‐Vance
- Changiz Geula
- Marla Gearing
- Farid Rajabli
- Fulai Jin
- Margaret E Flanagan
- David A. A. Bennett
- Xiaoxiao Liu
Institutions
- Northwestern University (US)
- Rush University Medical Center (US)
- University of Miami (US)
- Emory University (US)
- Dr. John T. Macdonald Foundation (US)
- Institute on Aging (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105108
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00