An overview and history of the Global Neurodegeneration Proteomics Consortium (GNPC)

With over 300,000,000 unique protein measures, the GNPC represents the one of the largest protein biomarker discovery efforts for neurodegenerative diseases-or any specific disease area-to date. Results of preliminary analyses from the consortium's distinct workstreams (cross-sectional profiling, longitudinal profiling, proteogenomic mapping, multivariate prediction & modeling) will be summarized, including diagnostic and predictive proteomic biomarker signatures for pan-neurodegeneration and disease-specific states.