Systemic bacterial infection induces cerebrovascular dysfunction and exaggerated neuroinflammation in APP/PS1 mice
This study shows that APP/PS1 mice with a systemic bacterial infection have exaggerated microglial neuroinflammatory response. The cerebrovascular dysfunction and fibrin- mediated activation of microglia following exposure to Salmonella Typhimurium may have contributed to this exaggerated neuroinflammatory response.
Authors
- Jessica L. Teeling (ORCID: https://orcid.org/0000-0003-4004-7391)
- Aaron B. Kantor
- Matthew P Colley
Institutions
- Shriners Hospitals for Children - Erie (US)
- University of Southampton (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105435
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00