Associations between tau PET and CSF MTBR243 do not vary by sex

Across two cohorts we found that sex did not moderate the relationship between tau-PET and CSF MTBR-tau243, two distinct markers of aggregated tau pathology. This suggests the sex effects found in tau-PET likely represent a true biological finding not specifically tied to tau-PET methodology.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_098213
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Associations between tau PET and CSF MTBR243 do not vary by sex

Ellen H. Singleton, Chihiro Sato, Rik Ossenkoppele, Erik Stomrud et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Associations between tau PET and CSF MTBR243 do not vary by sex

Ellen H. Singleton, Chihiro Sato, Rik Ossenkoppele, Erik Stomrud, Carling G. Robinson, Kanta Horie, Oskar H. Hansson, Alexa Pichet Binette, Niklas Mattsson‐Carlgren, Sebastian Palmqvist, Randall J. Bateman, Brian A. Gordon, Shorena Janelidze, Tammie L.S. Benzinger, Nicolas R. Barthélemy, Suzanne E. Schindler
article en

Abstract

Across two cohorts we found that sex did not moderate the relationship between tau-PET and CSF MTBR-tau243, two distinct markers of aggregated tau pathology. This suggests the sex effects found in tau-PET likely represent a true biological finding not specifically tied to tau-PET methodology.

Alzheimer s & DementiaVol. 21(S2)
Lund University (SE), Washington University in St. Louis (US), Amsterdam Neuroscience (NL), Institut Universitaire de Gériatrie de Montréal (CA), Skåne University Hospital (SE), Eisai (United States) (US), Amsterdam University Medical Centers (NL), Université de Montréal (CA), Vrije Universiteit Amsterdam (NL)
Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
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Associations between tau PET and CSF MTBR243 do not vary by sex — Ellen H. Singleton, Chihiro Sato, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS