Retinal Layer Thickness and PET Centiloid Values in Cognitively Unimpaired Older Adults
The significant relationship between mRNFL and centiloid values aligned with previous work showing mRNFL thinning in MCI and AD. This is the first study to examine this relationship in a preclinical population. Retinal OPL findings replicate prior research by our group which demonstrated a relationship between OPL thickness and plasma ptau217, an indicator of cerebral amyloidosis. Further studies of longitudinal changes are needed to validate retinal biomarkers in preclinical AD.
Authors
- Matthew R. Brier (ORCID: https://orcid.org/0000-0001-5987-8705)
- Abraham Z. Snyder (ORCID: https://orcid.org/0000-0002-3379-9627)
- Jordan Sergio
- Louisa I. Thompson (ORCID: https://orcid.org/0000-0002-7231-870X)
- Megan Stradtman
- Cyrus A. Raji (ORCID: https://orcid.org/0000-0002-9086-0105)
- Paul K. Commean
- Alyssa N. De Vito (ORCID: https://orcid.org/0000-0002-4078-3869)
- Jessica Alber (ORCID: https://orcid.org/0000-0002-5090-4206)
- Peter J. Snyder (ORCID: https://orcid.org/0000-0003-0555-4654)
- Mahshid Naghashzadeh
- Tammie L.S. Benzinger
- Savannah Doster
- Mahsa Dolatshahi
- Sheng‐Kwei Victor Song
- Ashley N. Price
Institutions
- University of Rhode Island (US)
- Providence College (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Butler Hospital (US)
- Mallinckrodt (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101202
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00