Intrinsic hypoexcitability of thalamic nucleus reuniens inputs to hippocampal CA1 in the 5xFAD mouse model of amyloidosis
Excitatory flow from nRT to CA1 is reduced in the setting of amyloidosis due to reduced intrinsic low threshold burst and spike firing within the nRT. In contrast, the relative stability of nRT→CA1 synapse itself suggests that this pathway may serve as a salvage mechanism to excite distal CA1 dendrites in the setting of compromised EC→CA1 excitation.
Authors
- Arjun V. Masurkar (ORCID: https://orcid.org/0000-0002-2498-2059)
- Isabel Reyes
- Chengju Tian
- Mohankumar Thangavel
Institutions
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106177
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00