Associations between co‐pathology and diagnostic concordance in neurodegeneration: post‐mortem analysis of the Amsterdam dementia cohort
Our results highlight the pathological heterogeneity within a large memory clinic cohort, and show that neurodegenerative diseases rarely present in isolation. Although diagnostic discordance was not explained by the number of co-pathologies or age at death, additionally investigating severity of co-pathologies might provide insight into interactions between co-pathologies and clinical phenotypes.
Authors
- Annemieke J.M. Rozemüller (ORCID: https://orcid.org/0000-0003-2528-4428)
- Afina W. Lemstra (ORCID: https://orcid.org/0000-0002-8933-3260)
- Everard G.B. Vijverberg (ORCID: https://orcid.org/0000-0003-3879-884X)
- Michelle Barboure
- Willem L. Hartog
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Hannah de Bruin (ORCID: https://orcid.org/0000-0002-9011-1120)
- Georgia Malliou
- Wiesje M. van der Flier
- Betty M. Tijms
- Argonde C. van Harten
- Sanne M.M. Vermorgen
Institutions
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Ludwig-Maximilians-Universität München (DE)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105443
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00