Haptoglobin Structural Variant Modifies APOE Risk Effect in 5155 Non‐Hispanic White and 4133 African Americans
We find that a structural variant of HP modifies the risk effect of APOE alleles. Our findings in an independent dataset corroborate elements of our previous discovery of this interaction effect.
Authors
- Penelope Benchek (ORCID: https://orcid.org/0000-0002-7385-087X)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Haimeng Bai (ORCID: https://orcid.org/0000-0003-2833-0813)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Yuchen Yang (ORCID: https://orcid.org/0000-0002-4930-7818)
- Margaret A. Pericak‐Vance
- Lindsay AA. Farrer
- Gerald D. Schellenberg
- Jonathan L Haines
Institutions
- Boston University (US)
- University of Miami (US)
- Columbia University Irving Medical Center (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106626
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00