The Multifactorial Impact of ApoE4 on Alzheimer's Pathology and Cognitive Decline
These findings highlight the multifactorial impact of ApoE4 in AD, demonstrating that humanized App<sup>NL-F</sup>/MAPT/ApoE4 mice exhibit biochemical and imaging biomarkers of pathology and a time course of neurodegeneration and cognitive dysfunction that reproduces a human-like phenotype of late onset AD. This work underscores the value of combining these novel mouse models with translational imaging and cognitive biomarkers for understanding the relationship between pathophysiology and high-level cognitive function.
Authors
- Mark Longmuir
- Ali R. Khan (ORCID: https://orcid.org/0000-0002-0760-8647)
- Arash Salahinejad (ORCID: https://orcid.org/0000-0001-7644-1273)
- Vânia F. Prado (ORCID: https://orcid.org/0000-0003-4994-6393)
- Scheila Schmidt
- Tallulah Andrews (ORCID: https://orcid.org/0000-0003-1120-2196)
- Bryan Lung
- Aya Arrar
- Lisa M Saksida
- Taylor W. Schmitz
- Marco AM Prado
- Kellly Summers
- Kate M. Onuska
- Timothy J Bussey
- Amr Eed
- Ravi S. Menon
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- Robarts Clinical Trials (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105101
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00