Alzheimer's disease and neurodegenerative plasma biomarkers predict altered sleep neurophysiology in older adults with subjective and objective cognitive impairment
The findings suggest REM slowing is a robust marker linked to plasma Aβ42/40, highlighting its potential as an early indicator of neuropathological changes. Aligned with prior research, REM slowing may reflect pathological changes driven by amyloid accumulation, contributing to disrupted cholinergic signalling. Longitudinal studies are needed to determine the causal relationship between sleep neurophysiology and plasma biomarkers of AD and neurodegeneration.
Authors
- Johannes C. Michaelian (ORCID: https://orcid.org/0000-0001-5683-8222)
- Aaron Lam (ORCID: https://orcid.org/0000-0001-6087-3565)
- Sharon L. Naismith (ORCID: https://orcid.org/0000-0001-9076-2778)
- Rachael Yu
- Angela D'Rozario
- Nathan Cross
Institutions
- The University of Sydney (AU)
- Woolcock Institute of Medical Research (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101696
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00