Study on the Therapeutic Effect and Mechanism of Gu Pi Sheng Ji Hua Zhuo Jie Du Decoction in Inducing Remission of Crohn’s Disease

This study suggests that GHD may induce remission in CD through a multi-component, multi-target mechanism, particularly by modulating pathways related to CASP1 and IDO1, thereby improving clinical symptoms and endoscopic findings. The underlying mechanism may involve regulation of the intestinal immune-inflammatory microenvironment. GHD holds promise as a potential traditional Chinese medicine strategy for treating CD, but further validation in larger randomized controlled trials is warranted.