Sex Differences in the Impact of Cardiometabolic Burden on Cognition in Persons 55+
Sex and increasing CMB differentially predicted domain-level cognitive deficits, with female sex conferring increased vulnerability in visuoperceptual abilities. While cardiometabolic conditions were similarly prevalent in both sexes, their impact on cognition varied. These results underscore the importance of reducing CMB to promote brain health and the need for tailored cognitive assessment and intervention. Future research should investigate underlying mechanisms of noted sex differences, including potential hormonal influences, vascular factors, and sex-specific inflammatory responses.
Authors
- Franchesca Arias (ORCID: https://orcid.org/0000-0002-5448-6849)
- Robert M. Bilder (ORCID: https://orcid.org/0000-0001-5085-7852)
- Adriana M. Strutt (ORCID: https://orcid.org/0000-0003-2108-1922)
- Paola Suárez (ORCID: https://orcid.org/0000-0002-1543-1044)
- Stella M. Garriga
- J. Block (ORCID: https://orcid.org/0000-0001-5741-9185)
- Brittany Wolff (ORCID: https://orcid.org/0000-0003-4579-7845)
- Lauren G Santos (ORCID: https://orcid.org/0000-0003-0454-1704)
- Lucia Cavanagh (ORCID: https://orcid.org/0000-0002-4109-8169)
- Laura Glass Umfleet (ORCID: https://orcid.org/0000-0001-7943-0406)
Institutions
- Baylor University (US)
- University of California, Los Angeles (US)
- Medical College of Wisconsin (US)
- University of Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_101005
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00