Exploring the role of MRI to optimize the design of clinical trials for progressive supranuclear palsy and corticobasal degeneration
Selecting participants with increased diagnostic certainty for PSP and CBD based on baseline MRI, combined with using MRI measures as outcomes could enhance the efficiency of future phase 2 clinical trials for 4R tauopathies. We plan to replicate these results in the Davunetide trial cohort.
Authors
- Sara Rubio‐Guerra (ORCID: https://orcid.org/0000-0001-7652-8029)
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- Olivia Belbin (ORCID: https://orcid.org/0000-0002-6109-6371)
- Michael Donohue (ORCID: https://orcid.org/0000-0001-6026-2238)
- Ignacio Illán‐Gala (ORCID: https://orcid.org/0000-0002-5418-2052)
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-5730-5388)
- Oriol Dols‐Icardo (ORCID: https://orcid.org/0000-0003-2656-8748)
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Judit Selma‐González (ORCID: https://orcid.org/0009-0006-1021-4653)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- REMA RAMAN (ORCID: https://orcid.org/0000-0002-4096-6390)
- Jesus Garcia Castro
- Daniel Alcolea
- Alberto Lleó
- Eden V. Barragan
- Miguel A Santos‐Santos
- Isabel Sala
- Irene Litvan
- Lídia Vaqué‐Alcázar
- Anne‐Marie Wills
- María Belén Sánchez‐Saudinós
- Lawren VandeVrede
- Adam L. Boxer
- Alejandra O. Morcillo‐Nieto
Institutions
- University of Southern California (US)
- Universitat Autònoma de Barcelona (ES)
- University of California, San Francisco (US)
- Hospital de Sant Pau (ES)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- University Memory and Aging Center (US)
- Southern States University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104263
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00