The role of metabolites in the causal effect of immune cell phenotypes on immunotherapy toxicity risk
This study suggests causal relationships between immune cell phenotypes, metabolites and irAEs. Two metabolites that may act as potential mediating factors between immune cells and high-grade irAEs were identified. Of course, further investigation is warranted to validate these results.
Authors
- Chen Cui (ORCID: https://orcid.org/0000-0002-4469-3967)
- Jinyi Zhao
- Rui Gong (ORCID: https://orcid.org/0009-0005-3690-3249)
- Fei Mu
- Kexin Sun
- Zhen Yan
- Meng Tang
- JingWen Wang
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1007/s12672-025-04319-9
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00