Subgroup Identification in Alzheimer's Disease Trial
The ITree-MMRM framework successfully identified MCI subgroups with differential long-term responses to Donepezil, providing insights into targeted treatment strategies for AD progression. These findings emphasize the potential of personalized medicine in improving therapeutic outcomes for MCI and AD, warranting further validation in larger clinical trials.
Authors
- Lei Liu (ORCID: https://orcid.org/0000-0001-6764-3260)
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099562
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00