Fingernail‐based Metabolomics Reveals a Stepwise Decline in Dodecanoic Acid Associated with Alzheimer's Disease Progression
Dodecanoic acid emerges as a critical biomarker reflecting disrupted fatty acid metabolism in AD progression. By leveraging fingernail metabolomics for long-term metabolic profiling, this non-invasive strategy offers a scalable approach for early diagnosis, staging, and monitoring of neurodegenerative diseases.
Authors
- Zhangjing Deng (ORCID: https://orcid.org/0009-0007-8161-8329)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7800-3189)
- Weihua Yu
- Jiani Wu
- Yang Lü
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101814
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00