Computational perivascular space volumes derived from magnetic resonance imaging relate to lower cognitive performance and cognitive decline ‐ A multicentre individual patient data meta‐analysis
The volume of MRI-visible PVS impacts ageing, vascular or neurogenerative processes leading to cognitive decline. More longitudinal data are needed to confirm the association. Other PVS measures should be assessed as these may be more sensitive to cognitive decline.
Authors
- J. Wardlaw
- Rosalind Brown (ORCID: https://orcid.org/0000-0002-7688-4864)
- Lucia Ballerini (ORCID: https://orcid.org/0000-0002-1956-4012)
- Francesca M. Chappell (ORCID: https://orcid.org/0000-0002-7742-1757)
- Hugo J. Kuijf (ORCID: https://orcid.org/0000-0001-6997-9059)
- Joel Ramirez (ORCID: https://orcid.org/0000-0002-5582-1776)
- Stephanie Berberian
- José Bernal (ORCID: https://orcid.org/0000-0002-8618-3543)
- Maria del C. Valdés Hernández
- Lauren Abby Woods
- G. Biessels
- Roberto Duarte
- Alberto De Luca
- Sandra E. Black
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Scarborough Health Network (CA)
- German Center for Neurodegenerative Diseases (DE)
- Health Sciences Centre (CA)
- University Medical Center Utrecht (NL)
- UK Dementia Research Institute (GB)
- Ontario Brain Institute (CA)
- University for Foreigners Perugia (IT)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099155
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00