The Role of NF1 and VCP in Frontotemporal Dementia

In FTLD/AD patients neurofibromin and VCP are mislocalized away from synapses in neurons. Understanding how this contributes to ER-associated proteostasis failures provides a promising avenue for therapeutic development.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_107275
Primary Topic
Endoplasmic Reticulum Stress and Disease
Type
article
Field-Weighted Citation Impact
0.00
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article

The Role of NF1 and VCP in Frontotemporal Dementia

Dariusz Pytel, Shelby Carter, William Hill, Jody F Longo
Alzheimer s & Dementia
Endoplasmic Reticulum Stress and Disease
article

The Role of NF1 and VCP in Frontotemporal Dementia

Dariusz Pytel, Shelby Carter, William Hill, Jody F Longo
article en

Abstract

In FTLD/AD patients neurofibromin and VCP are mislocalized away from synapses in neurons. Understanding how this contributes to ER-associated proteostasis failures provides a promising avenue for therapeutic development.

Alzheimer s & DementiaVol. 21(S1)
Medical University of South Carolina (US)
Openalex Percentile: Top 34%
Endoplasmic Reticulum Stress and Disease
DOIOpen Access PDFOpenAlex
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The Role of NF1 and VCP in Frontotemporal Dementia — Dariusz Pytel, Shelby Carter, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS