The Neuroprotective potentiality of β‐hydroxy β‐methyl butyrate in an Alzheimer's disease mouse model

According to our findings, HMB promotes synaptic protein expression and regulates CREB phosphorylation, potentially regulating brain plasticity and leading to cognitive recovery in AD models. Finally, our results suggested that the HMB is a strong and safe supplement, more investigation on its potential benefits for treating Alzheimer's appears to be desirable.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_098487
Primary Topic
Diet and metabolism studies
Type
article
Field-Weighted Citation Impact
0.00
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article

The Neuroprotective potentiality of β‐hydroxy β‐methyl butyrate in an Alzheimer's disease mouse model

Ramesh Kumar Paidi, Kalipada Pahan
Alzheimer s & Dementia
Diet and metabolism studies
article

The Neuroprotective potentiality of β‐hydroxy β‐methyl butyrate in an Alzheimer's disease mouse model

Ramesh Kumar Paidi, Kalipada Pahan
article en

Abstract

According to our findings, HMB promotes synaptic protein expression and regulates CREB phosphorylation, potentially regulating brain plasticity and leading to cognitive recovery in AD models. Finally, our results suggested that the HMB is a strong and safe supplement, more investigation on its potential benefits for treating Alzheimer's appears to be desirable.

Alzheimer s & DementiaVol. 21(S5)
Rush University Medical Center (US), Jesse Brown VA Medical Center (US)
Openalex Percentile: Top 33%
Diet and metabolism studies
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