Increased Risk of Cognitive Decline in APOE ε2 Homozygotes with African Local Ancestry: Insights from a Brazilian Population

Our results highlight the importance of considering local ancestry in genetic studies of complex diseases, especially in admixed populations like Brazil. This study provides new insights into the role of APOE ε2 homozygosity and local ancestry in modulating disease risk, with potential implications for personalized medicine and public health strategies.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_107131
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Increased Risk of Cognitive Decline in APOE ε2 Homozygotes with African Local Ancestry: Insights from a Brazilian Population

Renata Elaine Paraízo Leite, Cláudia Kimie Suemoto, Sonia Paco, Mayana Zatz et al.
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Increased Risk of Cognitive Decline in APOE ε2 Homozygotes with African Local Ancestry: Insights from a Brazilian Population

Renata Elaine Paraízo Leite, Cláudia Kimie Suemoto, Sonia Paco, Mayana Zatz, Michel Satya Naslavsky, LAMP4, Gabriel do Nascimento Santos, Marvin A.L.S. Alexandria, Isadora Bianchi Ignácio, Lucas Aurélio Veronezz
article en

Abstract

Our results highlight the importance of considering local ancestry in genetic studies of complex diseases, especially in admixed populations like Brazil. This study provides new insights into the role of APOE ε2 homozygosity and local ancestry in modulating disease risk, with potential implications for personalized medicine and public health strategies.

Alzheimer s & DementiaVol. 21(S1)
Universidade de São Paulo (BR), Hospital Israelita Albert Einstein (BR), Microsoft (Brazil) (BR), Universidade Cidade de São Paulo (BR), Hospital Universitário da Universidade de São Paulo (BR), Brazilian Institute of Neuroscience and Neurotechnology (BR), Centro de Genomas (Brazil) (BR)
Openalex Percentile: Top 33%
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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Increased Risk of Cognitive Decline in APOE ε2 Homozygotes with African Local Ancestry: Insights from a Brazilian Population — Renata Elaine Paraízo Leite, Cláudia Kimie Suemoto, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS