Integrate Real‐World Data and Genetics: a causal machine learning approach to assess Statin’s Effect on Incident Dementia
Our emulated trial indicated that statins did not demonstrate a protective effect against incident dementia in overall population. However, a subpopulation with high nonAPOE-PRS (which predicts AD dementia) and healthy dietary habits may benefit from statins use.
Authors
- Y. Lai
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Guorong Wu
- Til Stürmer
- Tiansheng Wang
- Gwenn A Garden
- Yang Xu
Institutions
- University of North Carolina at Chapel Hill (US)
- Peking University (CN)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_098710
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00