Wild type human tau is more prone to phosphorylation than P301L‐tau in the presence of amyloidosis in mouse brain

Over-expression of both wild-type and P301L tau induced learning and memory deficits in middle-aged APP+PS1 mice with mature amyloid pathology. While we observed less total tau in mice injected with AAV-WT than AAV-P301L, a greater fraction of the total available pool of tau was phosphorylated in mice over-expressing wild-type tau. These data suggest that although mutant P301L tau may be more prone to aggregation in vitro, WT-tau is more prone to phosphorylation in vivo in the presence of amyloidosis.