Analyze the binding of amyloid beta 1‐42 to specific regions of the TREM2 gene

We showed that Aβ interacted with the regulatory DNA regions of the TREM2 gene, including the enhancer located upstream, intron 2, and non-coding exon 5. The signal from the enhancer region was higher than that from the others. (Fold enrichment values above 3 were considered binding signals.) CONCLUSION: Our results showed that Aβ interacts with the regulatory DNA regions of the TREM2 gene. The data obtained will contribute to the identification of a new mechanism, beyond the receptor-ligand relationship, involving Aβ and TREM2 in the pathological mechanisms of AD, and to the understanding of complex processes related to AD. Our study is also expected to provide insights into TREM2-related therapeutic approaches for AD. This study is supported by the Health Institutes of Türkiye (TUSEB) (Project ID: 37319).