Neurotransmitter Dysregulation in Alzheimer's Disease: A Meta‐Analysis of Serotonin, Dopamine, and Norepinephrine Alterations Across Brain Regions
Serotonin, dopamine, and norepinephrine levels were significantly reduced in specific brain regions in AD. The most substantial decrease in serotonin was observed in the hippocampus, thalamus, temporal, and frontal regions. Dopamine levels were notably reduced in the temporal and frontal regions, while norepinephrine showed significant reductions in the hippocampus, thalamus, and frontal regions. Further validation of these findings is required.
Authors
- Mainak Bardhan (ORCID: https://orcid.org/0000-0002-4106-409X)
- Harshita Agarwal
- Victor Ghosh (ORCID: https://orcid.org/0000-0003-0914-1056)
- Anmol Kaur
- Poorvikha Gowda
- Vinay Suresh (ORCID: https://orcid.org/0000-0002-1401-9154)
- P.N. Yadav
- Mohammad Orooj Azmi
- Ahmed Y. Azzam
- Alzheimer's Interest and Analytics Group ‐ NeuroStats Network
- Mohammad Hassan
- Muneeb Ahmad Muneer
Institutions
- Andhra University (IN)
- Lady Hardinge Medical College (IN)
- Baptist Hospital of Miami (US)
- Albert Einstein College of Medicine (US)
- Allama Iqbal Medical College (PK)
- Government of Uttar Pradesh (IN)
- Maulana Azad Medical College (IN)
- Baptist Health South Florida (US)
- Institute of Post Graduate Medical Education and Research (IN)
- Jawaharlal Nehru Medical College (IN)
- St.John's Medical College Hospital (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100337
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00