Exploring molecular signatures of vulnerable vs resilient RORB excitatory neurons of the entorhinal cortex in Alzheimer's disease

Our findings suggest that transcriptomic signatures of vulnerable and resilient RORB excitatory neurons in the EC, in early Braak stages, may reveal key pathways leading to tau accumulation and neuronal loss. Notably, vulnerable RORB neurons upregulated cytoskeletal organization pathways and downregulated proteostasis pathways. Ongoing analyses on this RORB subpopulation and trajectory analyses on additional excitatory neuronal subpopulations in the EC will refine our understanding of the pathways that potentially lead to selective vulnerability in AD.