Prospective associations of epigenetic age estimators with Alzheimer's disease atrophy patterns among older women: The Women's Health Initiative Memory Study
AgeAccelGrim2 predicted atrophy in brain regions vulnerable to AD∼8 years later in cognitively healthy women. In a companion study, we found that AgeAccelGrim2 predicted development of MCI/dementia in these women. These findings suggest that this blood-derived epigenetic measure of accelerated aging may serve as an early biomarker of AD risk and provide further evidence of detrimental associations of smoking with brain health in aging.
Authors
- Linda K. McEvoy (ORCID: https://orcid.org/0000-0003-4583-7798)
- Ramon Casanova (ORCID: https://orcid.org/0000-0002-6934-5942)
- Kenneth B. Beckman (ORCID: https://orcid.org/0000-0001-8876-0706)
- Stephen R. Rapp (ORCID: https://orcid.org/0000-0002-9766-3104)
- M E Espeland
- Bowei Zhang (ORCID: https://orcid.org/0000-0002-3120-4538)
- Ake Lu
- Steve Horvath
- Steve Nguyen
- Adam Maihofer
- Aladdin H. Shadyab
- Andrea Z. LaCroix
- Susan M. Resnick
- Caroline Nievergelt
Institutions
- National Institutes of Health (US)
- University of Minnesota (US)
- Kaiser Permanente Washington Health Research Institute (US)
- University of California San Diego (US)
- Cambridgeshire County Council (GB)
- National Institute on Aging (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099085
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00