Fluid biomarkers of peripheral and central inflammation over the Alzheimer's disease continuum in adults with Down syndrome
Inflammation was detectable in plasma and CSF in adults with DS prior to AD onset and over the AD continuum. Inflammation scores in the CSF reflect AD pathophysiological changes in DSAD even prior to AD onset.
Authors
- Olivia Belbin (ORCID: https://orcid.org/0000-0002-6109-6371)
- Bessy Benejam (ORCID: https://orcid.org/0000-0002-6789-8615)
- Natalia Valle‐Tamayo
- Lucía Maure‐Blesa
- Laura Videla (ORCID: https://orcid.org/0000-0002-9748-8465)
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- Florencia Iulita
- Miren Edurne Ariño Altuna (ORCID: https://orcid.org/0000-0002-7613-7869)
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Daniel Alcolea
- Alberto Lleó
- Oriol Dols‐Icardo
- Aida Sanjuan Hernandez
- Íñigo Rodríguez‐Baz
- Laura Del Hoyo
Institutions
- Universitat Autònoma de Barcelona (ES)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099361
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00