OPRM1 A118G Polymorphism and Ondansetron Efficacy for Postoperative Nausea and Vomiting in Laparoscopic Gynaecological Surgery: A Retrospective Cohort Study
The OPRM1 A118G polymorphism is associated with an increased risk of early PONV, particularly in patients with the G allele, which has been related to reduced μ-opioid receptor sensitivity and increased opioid requirements, thereby predisposing patients to a higher PONV risk. Ondansetron significantly reduces PONV incidence and severity, especially in patients with higher genetic susceptibility.
Authors
- Chengxiao Liu (ORCID: https://orcid.org/0000-0002-9067-533X)
- Wenjia Zhang
- Qingqing Yu (ORCID: https://orcid.org/0000-0001-5695-6747)
- Guanling Yu
- Zunsai Feng
- Xu Zhao
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Therapeutics and Clinical Risk Management
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/tcrm.s551616
- Primary Topic
- Nausea and vomiting management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province