Charactering the interaction between expression quantitative trait loci and Alzheimer's Disease Status
Our eQTL analysis revealed substantial cohort-related differences in whole blood gene expression regulation, including numerous cohort-specific ieQTL effects. These findings suggest that genetic variation may modulate immune-related pathways relevant to AD pathogenesis. This underscores the need for multi-cohort studies to inform the development of effective AD therapies.
Authors
- Concepcion Silva
- Tianjie Gu
- Maryenela Illanes‐Manrique (ORCID: https://orcid.org/0000-0002-3098-0981)
- Yousef Mustafa (ORCID: https://orcid.org/0000-0002-5935-7069)
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Nicholas R. Wheeler (ORCID: https://orcid.org/0000-0003-2248-8919)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Makaela Mews (ORCID: https://orcid.org/0009-0006-6416-7581)
- Lissette Gomez
- Mario Cornejo‐Olivas
- Goldie S Byrd
- Margaret Pericak‐Vance
- Jonathan L Haines
- Larry D Adams
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Dr. John T. Macdonald Foundation (US)
- Instituto Nacional de Ciencias Neurológicas
- Wake Forest University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106835
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00