Impairment of glymphatic function supported by sleep oscillatory circuits in Alzheimer's disease
Our findings provide crucial evidence for potential neural interactions between sleep oscillatory circuits and the glymphatic system, with this effect being diminished in Alzheimer's disease (AD) patients. Specifically, the reduced precision of SO-spindle coupling in AD patients may represent a key mechanism driving the impaired glymphatic clearance of white matter, contributing to cognitive decline.
Authors
- Tao Wei (ORCID: https://orcid.org/0000-0001-8094-4906)
- Xing Liu (ORCID: https://orcid.org/0000-0002-7480-5085)
- Yi Tang (ORCID: https://orcid.org/0000-0002-2580-7420)
Institutions
- Capital Medical University (CN)
- Ministry of Civil Affairs (CN)
- Beijing Anding Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_100800
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00