Women with Down syndrome show more severe Alzheimer's disease neuropathology with regional differences

Together, these results suggest women with DSAD may have a more severe pathologic burden, specifically in the occipital cortex, an area typically affected later in AD pathogenesis, compared to men with DSAD. Future studies will be required to confirm this difference. Sex differences may also be region-specific, and sex should be considered in design and interpretation of future clinical trials.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_107096
Primary Topic
Down syndrome and intellectual disability research
Type
article
Field-Weighted Citation Impact
0.00
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article

Women with Down syndrome show more severe Alzheimer's disease neuropathology with regional differences

Julia Kofler, Miloš D. Ikonomović, Freddy Gonzalez, J Harp et al.
Alzheimer s & Dementia
Down syndrome and intellectual disability research
article

Women with Down syndrome show more severe Alzheimer's disease neuropathology with regional differences

Julia Kofler, Miloš D. Ikonomović, Freddy Gonzalez, J Harp, Jesse R. Pascual, Sierra Wright, Michael Phelan, P. D. Lao, Phong T. Ngo, Adam M Brickman, Elizabeth J. Andrews, Frederick A Schmitt, Elizabeth Head
article en

Abstract

Together, these results suggest women with DSAD may have a more severe pathologic burden, specifically in the occipital cortex, an area typically affected later in AD pathogenesis, compared to men with DSAD. Future studies will be required to confirm this difference. Sex differences may also be region-specific, and sex should be considered in design and interpretation of future clinical trials.

Alzheimer s & DementiaVol. 21(S1)
Alzheimer's Association (US), University of Kentucky (US), University of Pittsburgh (US), University of California, Irvine (US), Massachusetts General Hospital (US), Columbia University (US)
Openalex Percentile: Top 26%
Down syndrome and intellectual disability research
DOIOpen Access PDFOpenAlex
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Women with Down syndrome show more severe Alzheimer's disease neuropathology with regional differences — Julia Kofler, Miloš D. Ikonomović, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS