Sex‐specific patterns of a machine learning‐derived Alzheimer's brain atrophy imaging signature in participants without diagnosed cognitive impairment: A multi‐cohort study
SPARE-AD scores increased with age and were higher in women at younger ages but lower than men at older ages, with a significant age*sex interaction, and were positively associated with the number of the APOE ε4 allele, particularly in men.
Authors
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Ajay Gupta (ORCID: https://orcid.org/0000-0001-6074-9847)
- Haochang Shou
- Despina Kontos (ORCID: https://orcid.org/0000-0001-9031-5126)
- Sarah Ko (ORCID: https://orcid.org/0009-0009-8105-3924)
- Erdem Varol (ORCID: https://orcid.org/0000-0002-6128-8939)
- Andrew Zalesky
- Mehrshad Saadatinia
- Ye Ella Tian
- Adam Brickman
- Susan M. Resnick
- Guray Erus
- Junhao Wen
- Filippos Anagnostakis
- Li Shen
Institutions
- Intel (United States) (US)
- The University of Melbourne (AU)
- Institute on Aging (US)
- National Institute on Aging (US)
- Center for Innovation (US)
- New York Genome Center (US)
- Melbourne Health (AU)
- Artificial Intelligence in Medicine (Canada) (CA)
- New York University (US)
- Columbia University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098833
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00