Primary Endpoint and Analysis Model for Prevention Trials with Participants with Preclinical AD: Lessons Learned from the DIAN‐TU Platform Trial

Our experience from the DIAN-TU platform trial suggests that time-to-recurrent-event is a more effective endpoint for preclinical AD trials. Survival analysis provides more tangible and clinically relevant insights by translating treatment effects into reductions in hazard rates or extended survival times.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_099564
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Primary Endpoint and Analysis Model for Prevention Trials with Participants with Preclinical AD: Lessons Learned from the DIAN‐TU Platform Trial

Guoqiao Wang, Yan Li
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Primary Endpoint and Analysis Model for Prevention Trials with Participants with Preclinical AD: Lessons Learned from the DIAN‐TU Platform Trial

Guoqiao Wang, Yan Li
article en

Abstract

Our experience from the DIAN-TU platform trial suggests that time-to-recurrent-event is a more effective endpoint for preclinical AD trials. Survival analysis provides more tangible and clinically relevant insights by translating treatment effects into reductions in hazard rates or extended survival times.

Alzheimer s & DementiaVol. 21(S5)
Washington University in St. Louis (US)
Good health and well-being
Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Primary Endpoint and Analysis Model for Prevention Trials with Participants with Preclinical AD: Lessons Learned from the DIAN‐TU Platform Trial — Guoqiao Wang, Yan Li · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS