Dream recall in cognitively healthy older adults: associations with blood <i>p</i> ‐tau217 levels, <i>APOE</i> ε4 carriage, and cognitive decline
Dream recall status was associated with blood p-tau217 levels, APOE ε4 carriage, and future cognitive decline among older individuals cognitively healthy at baseline. Not remembering dreams in later life may be an early indicator of neurodegeneration in the DMN. This would help explain an unexpected and overlooked finding more than 30 years ago that lower dream recall frequency predicted incident dementia (Persson & Skoog, J Geriatr Psychiatry Neurol 1992;5:172-178), a decade before the DMN was discovered.
Authors
- Ashleigh S. Vella (ORCID: https://orcid.org/0000-0002-5653-5077)
- Mario Ricciardi (ORCID: https://orcid.org/0009-0008-5959-9245)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Pascual Sánchez‐Juan (ORCID: https://orcid.org/0000-0002-6081-8037)
- Belén Frades
- Darren M. Lipnicki (ORCID: https://orcid.org/0000-0002-1684-3577)
- Meritxell Valenti
- Teodoro del Ser (ORCID: https://orcid.org/0000-0001-9806-7083)
- Elizabeth Lucia Valeriano‐Lorenzo
- Sonia Wagner
- Marian Zea‐Sevilla
- Minerva Martinez
Institutions
- UNSW Sydney (AU)
- ARC Centre of Excellence in Synthetic Biology (AU)
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_097922
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00