Transcriptomic analysis from 3D cultures of Presilinin‐1 G206A carriers reveals genetic expression differences associated with age‐of‐onset variability
Our analysis identified transcriptomic changes between spheroid 3D cultures of early and late AOO G206A carriers in genes previously implicated in multiple studies of AD pathogenesis and neurodevelopmental disorders. Our results suggest that pathways involved in vascular morphogenesis, lipid processing, protein aggregation and neuronal regulation may be contributing to the variability in AD AOO observed in G206A carriers.
Authors
- Patrice Whitehead
- Michael Cuccaro
- Juan I. Young
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Katrina Celis
- Concepcion Silva‐Vergara
- Aura M. Ramírez (ORCID: https://orcid.org/0009-0007-8892-5743)
- Jeffery M. M Vance
- Brooke A. DeRosa (ORCID: https://orcid.org/0000-0002-7878-9799)
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Heriberto Acosta
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- C. Golightly (ORCID: https://orcid.org/0000-0001-6256-9153)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Younji Nam
- Katalina McInerney
- Margaret Pericak‐Vance
- Larry D Adams
- Farid Rajabli
- Jose J. Sanchez
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Dr. John T. Macdonald Foundation (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104923
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00