Disease‐Derived Tau Seeds Induce Aggregation and Pathway Disruptions in a Cellular Model
This approach provides a robust model for studying tau pathology in a disease-specific context. By eliminating tau overexpression, it provides a more physiologically relevant platform to investigate tau interactions and assess potential therapeutic strategies targeting aggregation and toxicity.
Authors
- Glenda Margaret Halliday (ORCID: https://orcid.org/0000-0003-0422-8398)
- Evgeny Kanshin (ORCID: https://orcid.org/0000-0001-7142-4554)
- Diba Ahmadi Rastegar
- Aysha Y. G. Strobbe (ORCID: https://orcid.org/0009-0004-7591-8796)
- Kaleah Balcomb (ORCID: https://orcid.org/0009-0003-7006-2776)
- Eleanor Drummond
- Beatrix Ueberheide
- Tomas Kavanagh
- He‐Shyan Balnave
Institutions
- The University of Sydney (AU)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106344
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00