Neuroinflammation is a Key Player in the Cognitive Fate of Individuals Who Harbor Alzheimer Disease Neuropathologic Changes
Based on the above findings, we propose that aberrant accumulation of pathological tau species in neurites and synapses may instigate a pro-inflammatory reaction of glial cells that involves activation of TNF and NF-κB signaling pathways and could determine the opposite cognitive fate (dementia vs. preserved cognition) of individuals who harbor ADNC as assessed at autopsy.
Authors
- Charles Klein
- Ibai Díez (ORCID: https://orcid.org/0000-0001-5769-0178)
- Teresa Gómez‐Isla (ORCID: https://orcid.org/0000-0002-7977-2075)
- Cinthya Agüero (ORCID: https://orcid.org/0000-0001-9483-429X)
- Sunny Kumar (ORCID: https://orcid.org/0000-0003-4930-8738)
- Ana Claudia Amaral
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- MaineGeneral Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107046
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00