Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p
Hypoxic preconditioning augments anti-apoptotic properties of exosomes, primarily <i>via</i> miR-486-5p upregulation, which mediates its function by modulating the phosphatase and tensin homolog/PI3K/Akt axis.
Authors
- Guoji Wang (ORCID: https://orcid.org/0009-0000-0976-5673)
- Hong-xiang HE
- Y. C. Liu
- Zhinong Wang (ORCID: https://orcid.org/0000-0001-6308-7949)
- P.‐J. Cheng
- Zi-Feng Zeng
- Xi-Bei Xia
- Jun-Nan Wang
- Jin Rao
- Qiong Chen
- Pei Wang
- Xiang-Yu Chen
- Bin Liu
- Yue Yu
Institutions
- University of Shanghai for Science and Technology (CN)
- Second Military Medical University (CN)
- Shanghai Changzheng Hospital (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-12-25
- DOI
- https://doi.org/10.4252/wjsc.v17.i12.112207
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00